Abstract: A major problem in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells（CSCs） can proliferate indefinitely, be proved enhancing chemoresistance and indicate a close relationship with chemoresistance. CSCs with definite cell surface maker can be separated from chemoresistant ovarian cancer cells, they can provide a reservoir of cells that can self-renew, maintain the tumor which make up the bulk of the tumor and may be the primary source of recurrence and chemoresistance. According to the special cell-surface marker and making chemotherapeutics selectively binding with ovarian cancer stem cells, can eliminate cancer recurrence and chemoresistance thoroughly and provide more effective chemotherapy shedules.

Key words: Ovarian neoplasms, Neoplastic stem cells, Drug resistance, neoplasm, Biological markers, Immunity