Abstract: Nerve growth factor（NGF）is a poly-peptide hormone of neurotrophin family. It can stimulate the growth of nerve fibers, besides, it also has the impact on certain kinds of tumor by autocrine and paracrine secretion, and result in the modulation of tumor generation, development and metastasis. Regarding the ovarian cancer, after bind to its receptor TrkA and p75, NGF can enhance the formation of cancer’s supplemental vessels, influence the level of cytokine, thereby it will play an important role in the development, invasion and metastasis of ovarian tumor. When we recognize the mechanism of NGF, it will open a new vision on ovarian tumor of early diagnosis, treatment and prognosis.

Key words: Ovarian neoplasms, Nerve growth factor, Receptor, trkA, Receptors, nerve growth factor