Abstract: Objective：To discuss the relationship between insulin, insulin-like growth factor Ⅰ（IGF-Ⅰ）, IGF-Ⅱ, Insulin-like growth factor binding protein 1 （IGFBP-1）, IGFBP-3 in maternal blood and newborn blood and fetal birth weight. To search their influence on fetal growth and development. Methods：230 cases who gave birth in Hangzhou First People′s Hospital were selected from January 2012 to February 2013, according to the relationship between birth weight and gestational age, they were divided into 3 groups, SGA group: 15 cases who were small for gestational age infants, AGA group: 162 cases who were appropriate for gestational age infants, the LGA groups: 53 cases who were large for gestational age infants. Maternal blood and cord blood insulin, IGF-Ⅰ, IGF-Ⅱ, IGFBP-1 and IGFBP-3 levels were detected by enzyme-linked immunosorbent assay. Results：The insulin, IGF-Ⅰ, IGF- Ⅱand IGFBP-3 level in the three groups of maternal and cord blood were different（all P＜0.001）. The LGA group was higher than the AGA group, and the AGA group was also higher than the SGA group （all P＜0.01）. Maternal blood IGF-Ⅱand cord blood insulin, IGF-Ⅰ, IGF-Ⅱ can influence fetal birth weight. Conclusions：Maternal blood IGF-Ⅱand cord blood insulin, IGF-Ⅰ, IGF-Ⅱ could be the key factors which can affect fetal growth and development.

Key words: Insulin, Insulin-like growth factor Ⅰ, Insulin-like growth factor Ⅱ, Insulin-like growth factor binding protein 1, Insulin-like growth factor binding protein 3, Birth weight