Abstract: Objective：To investigate the clinical effect of calcium gluconate combined with carboprost tromethamine on postpartum hemorrhage in preeclampsia cesarean section. Methods：160 pregnant women with preeclampsia who were terminated by cesarean section from September 2016 to September 2017 in our hospital were enrolled in this study, who were divided into study group and control group according to the random number table, each 80 cases. All pregnant women were terminated by cesarean section. After the fetus was delivered, the control group was given oxytocin and carboprost tromethamine, and the study group was given calcium gluconate on the basis of the control group. The amount of bleeding during the operation, 2 h and 24 h after surgery and the postpartum hemorrhage rate were compared between the two groups. The serum concentrations of Ca2+ and hemoglobin before and after cesarean section were compared between the two groups. The incidence of adverse reactions was compared between the two groups. Results：There was no significant difference in bleeding volume between study group and control group during operation (P＞0.05). The amount of bleeding in the study group was less than that in the control group at 2 h and 24 h after the operation (P＜0.05). The postpartum hemorrhage rate in the study group was 15.00% (12/80), and the postpartum hemorrhage rate in the control group was 36.25% (29/80), which was statistically different (χ2=9.477, P=0.002). After cesarean section, serum concentrations of Ca2+ increased in both groups, the study group was more significant than the control group (P＜0.05), hemoglobin content decreased in both groups, the control group decreased more than the study group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the study group (16.25%) and the control group (13.75%) (χ2=0.196, P=0.658). Conclusions：Calcium gluconate combined with carboprost tromethamine for preventing postpartum hemorrhage in pregnant women with preeclampsia has a better hemostatic effect, which is safe and effective and worthy of clinical promotion.

Key words: Pre-eclampsia, Cesarean section, Calcium gluconate, Postpartum hemorrhage, Carboprost tromethamine