Abstract: Postpartum hemorrhage (PPH) is one of the top reasons of maternal morbidity and death. Estimated blood loss more than 500 mL after vaginal birth and more than 1 000 mL after cesarean birth are currently used to define postpartum hemorrhage. The diagnosis not only depend on the blood loss volume, but also the change of ■ hemodynamics. Oxytocin, the gold standard for PPH prevention and treatment is accepted by majority of obstetrician, and carbetocin, carboprost tromethamine, misoprostol are also can be used. When the patient has high risk of PPH, in addition to the prevention of oxytocin during cesarean section, intrarenous tranexamic acid may also be considered to reduce bleeding. Because there is no evidence to support the best way among current operation methods, we should choose the pattern by practical conditions. Once PPH occurs, coagulopathy is the forecasting indicators for massive transfusion and hysterectomy, and an early fibrinogen concentrate infusion in uncontrolled active PPH is effective and safe. Discernment earlier, disposal comprehensively, estabilish the emergency management team, debriefs and staff training ars indispensable procedure in PPH management.

Key words: Postpartum hemorrhage, Oxytocin, Tranexamic acid, Blood coagulation, Operation