The Diagnostic Value of Platelet and Coagulation Indexes in Ovarian Endometriosis Cysts

doi:10.12280/gjfckx.20201128

Abstract

Abstract:

Objective：Discuss the value of platelet and coagulation parameters in diagnosis of ovarian endometriosis cysts. Methods: Patients with ovarian cyst treated by gynecologic surgery in the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from May 2013 to May 2017 were selected. Patients with ovarian endometriosis cysts confirmed by pathology after surgery were the observation group, patients with simple cysts were the control group. The parameters of two groups were compared: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), large platelet count (P-LCR), prothrombin time (PT), thrombin time (TT), activated partial thrombin time (APTT), fibrinogen (FIB), prothrombin international ratio (INR), plasma D-dimer and serum CA125. To evaluate the diagnostic value of platelet and coagulation parameters in ovarian endometriosis cysts. Results: Compared with the control group, PLT, PCT, CA125 were higher and PDW, APTT were lower in the observation group, the difference was statistically significant (P<0.05). Compared with the observation groupⅠ, Ⅱ, PLT, PCT and MPV were higher and PDW、P-LCR、APTT were lower in the observation group Ⅲ, Ⅳ, the difference was statistically significant (P<0.05). There was a positively correlated between CA125 and MPV,negative correlation between CA125 and PDW, P-LCR in the observation group. Compared with preoperative, postoperative PLT, PCT and MPV were lower, PDW, P-LCR were higher in observation group, the difference was statistically significant (P<0.05). Conclusions: The correlation between platelet and coagulation parameters and the incidence of ovarian endometriosis cysts has certain diagnostic value in clinic, but further study is needed.

Key words: Ovarian endometriosis cyst, Endometriosis, Ovarian cysts, Blood platelets, Blood coagulation tests, Diagnosis

WANG Ya-nan, SONG Dian-rong, ZHANG Wei. The Diagnostic Value of Platelet and Coagulation Indexes in Ovarian Endometriosis Cysts[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 597-600.

Figures/Tables 8

References 13

[1]	Habib N, Centini G, Lazzeri L, et al. Bowel Endometriosis: Current Perspectives on Diagnosis and Treatment[J]. Int J Womens Health, 2020,12:35-47. doi: 10.2147/IJWH.S190326. doi: 10.2147/IJWH.S190326
[2]	Vallée A, Lecarpentier Y. Curcumin and Endometriosis[J]. Int J Mol Sci, 2020,21(7):2440. doi: 10.3390/ijms21072440. doi: 10.3390/ijms21072440
[3]	张丽蓉, 王丹, 吴荣锋, 等. 雌激素与子宫内膜异位症关系的研究进展[J]. 中国医药科学, 2019,9(8):34-36. doi: 10.3969/j.issn.2095-0616.2019.08.010. doi: 10.3969/j.issn.2095-0616.2019.08.010
[4]	Yen CF, Kim MR, Lee CL. Epidemiologic Factors Associated with Endometriosis in East Asia[J]. Gynecol Minim Invasive Ther, 2019,8(1):4-11. doi: 10.4103/GMIT.GMIT_83_18. doi: 10.4103/GMIT.GMIT_83_18
[5]	Bazot M, Bharwani N, Huchon C, et al. European society of urogenital radiology (ESUR) guidelines: MR imaging of pelvic endometriosis[J]. Eur Radiol, 2017,27(7):2765-2775. doi: 10.1007/s00330-016-4673-z. doi: 10.1007/s00330-016-4673-z pmid: 27921160
[6]	Viganò P, Ottolina J, Sarais V, et al. Coagulation Status in Women With Endometriosis[J]. Reprod Sci, 2018,25(4):559-565. doi: 10.1177/1933719117718273. doi: 10.1177/1933719117718273 pmid: 28681683
[7]	Mitri F, Casper RF. Endometriosis and mild bleeding disorders[J]. Fertil Steril, 2015,103(4):886- 887.e1. doi: 10.1016/j.fertnstert.2015.02.037. doi: 10.1016/j.fertnstert.2015.02.037
[8]	王嵩, 宋殿荣. 血小板及相关因子功能的异常与子宫内膜异位症发病机制的关系[J]. 国际妇产科学杂志, 2018,45(3):279-282, 300. doi: 10.3969/j.issn.1674-1870.2018.03.010. doi: 10.3969/j.issn.1674-1870.2018.03.010
[9]	Zuin M, Rigatelli G, Stellin G, et al. Should women with endometriosis be screened for coronary artery disease?[J]. Eur J Intern Med, 2016,35:e19-e20. doi: 10.1016/j.ejim.2016.08.021. doi: 10.1016/j.ejim.2016.08.021
[10]	梁红梅, 黄华, 邓宝佳, 等. 急性心肌梗死患者C反应蛋白和血小板水平的测定及分析[J]. 国际检验医学杂志, 2015,36(14):1982-1983. doi: 10.3969/j.issn.1673-4130.2015.14.011. doi: 10.3969/j.issn.1673-4130.2015.14.011
[11]	Amreen S, Kumar P, Gupta P, et al. Evaluation of Oxidative Stress and Severity of Endometriosis[J]. J Hum Reprod Sci, 2019,12(1):40-46. doi: 10.4103/jhrs.JHRS_27_17. doi: 10.4103/jhrs.JHRS_27_17
[12]	Sanchez AM, Viganò P, Somigliana E, et al. The endometriotic tissue lining the internal surface of endometrioma: hormonal, genetic, epigenetic status, and gene expression profile[J]. Reprod Sci, 2015,22(4):391-401. doi: 10.1177/1933719114529374. doi: 10.1177/1933719114529374 pmid: 24700055
[13]	Taherkhani R, Farshadpour F, Makvandi M, et al. Determination of cytomegalovirus prevalence and glycoprotein B genotypes among ulcerative colitis patients in ahvaz, iran[J]. Jundishapur J Microbiol, 2015,8(2):e17458. doi: 10.5812/jjm.17458. doi: 10.5812/jjm.17458

组别	n	年龄（岁）	初潮年龄（岁）	BMI（kg/m²）
观察组	164	37.60±3.94	12.85±1.65	24.06±1.61
对照组	176	38.03±4.16	13.02±1.67	23.85±1.33
t		-0.965	-0.936	1.309
P		0.335	0.350	0.191

组别	n	年龄（岁）	初潮年龄（岁）	BMI（kg/m²）
观察组	164	37.60±3.94	12.85±1.65	24.06±1.61
对照组	176	38.03±4.16	13.02±1.67	23.85±1.33
t		-0.965	-0.936	1.309
P		0.335	0.350	0.191

组别	n	PLT（×10⁹/L）	PCT（%）	MPV（fL）	PDW（fL）	P-LCR（%）
观察组	164	254.47±52.08	0.25±0.04	10.05±0.84	11.60±1.85	25.49±6.22
对照组	176	235.39±50.41	0.23±0.02	10.19±0.98	11.99±2.10	26.46±7.01
t		3.433	5.249	-1.350	-1.798	-0.849
P		0.001	0.000	0.178	0.033	0.396

组别	n	PLT（×10⁹/L）	PCT（%）	MPV（fL）	PDW（fL）	P-LCR（%）
观察组	164	254.47±52.08	0.25±0.04	10.05±0.84	11.60±1.85	25.49±6.22
对照组	176	235.39±50.41	0.23±0.02	10.19±0.98	11.99±2.10	26.46±7.01
t		3.433	5.249	-1.350	-1.798	-0.849
P		0.001	0.000	0.178	0.033	0.396

期别	n	PLT（×10⁹/L）	PCT（%）	MPV（fL）	PDW（fL）	P-LCR（%）
Ⅰ、Ⅱ期	42	236.51±49.49	0.24±0.03	9.81±0.66	12.14±1.85	27.30±6.46
Ⅲ、Ⅳ期	122	260.66±51.70	0.25±0.04	10.14±0.88	11.42±1.81	24.86±6.03
t		-2.639	-2.349	-2.517	2.209	2.213
P		0.009	0.020	0.013	0.029	0.028