Abstract: Objective：To investigate the clinicopathological features, diagnosis, treatment and prognosis of female genital angiomyofibroblastoma (AMF). Methods：Retrospective analysis of the clinical data of 10 female genital AMF patients treated during January 2012 to October 2017, combined with related literatures, summarized their clinical and pathological features, diagnosis, treatment and prognosis. Results：The average onset age was (49.90±7.62) years old in 10 patients with AMF. The patients had no obvious clinical symptoms, and no specificity in imaging examination. Under the microscope, the cell-rich area and cell-sparse area were alternately distributed, the tumor tissue was composed of significantly small lumen, thin tube wall and dilated blood vessels which were surrounded by eosinophilic circular or fusiform tumor cells, and the tumor matrix was loose, edema and mucus like, and nuclear fission was rare. All the 10 patients underwent partial complete resection. 8 cases were followed up and the median follow-up time was 37 months. No recurrence occurred. Conclusions：There is no specificity in the clinical manifestation and imaging of AMF which occurs in female genital organs. The diagnosis and differential diagnosis mainly depends on the pathological features and immunohistochemistry. The surgical treatment is the main treatment and the prognosis is good.

Key words:  Pathology, clinical, Diagnosis, Angiomyofibroblastoma