Abstract: Gestational diabetes mellitus（GDM） is defined as an endocrine metabolic disease with glycometabolism disorder in varied degrees which firstly occur or is identified during pregnancy. It is a serious but common threat to the health of mother and fetal. Recent research shows that increased insulin resistance（IR） caused by abnormal adipose cytokines secretion might be one of the pathogenesis of GDM. Vaspin（visceral adipose tissue-derived serine protease inhibitor）, as a newly discovered adipose cytokines with insulin-sensitizing and improving insulin resistance effects, probably plays an important role in the development of type 2 diabetes and GDM. Recently, there are some researches between vaspin and GDM, but the results are different. This review is aimed to summarize the change of vaspin during pregnancy and the relationship between vaspin and GDM.

Key words: Vaspin, Diabetes, gestational, Insulin resistance, Adipokines, Adipose tissue