Abstract: Objective：To systematically review the association between rs266729(-11377C/G) of adiponectin gene and gestational diabetes mellitus (GDM). Methods: We electronically searched the following databases: PubMed, Web of Science, CBM, CNKI, WanFang Data, and VIP to identify all the case-control trials which was related to the association between rs266729(-11377C/G) of adiponectin gene and GDM. Two reviewers independently filtrated literature and extracted data according to the inclusion and exclusion criteria. Then, they assessed the quality of the included studies and performed meta-analysis using RevMan 5.3 software. Results: Totally 7 studies were recruited (943 GDM pregnant women and 999 normal pregnant women), including two Chinese studies and five English studies. The results of meta-analysis showed that there was no significant difference in the genotype frequency of rs266729(-11377C/G) between the two groups. The pooled OR values and 95%CI values of GG vs. GC, GG vs. CC and GC vs. CC were 0.87 (0.59-1.28), 1.03 (0.71-1.48), 1.12 (0.91-1.39), respectively. There was also no significant difference in the dominant and recessive genetic models between the two groups. The pooled OR value of dominant genetic model was 1.22 (0.98-1.51), and the pooled OR value of recessive genetic model was 0.95 (0.66-1.36). For the allele frequencies, a significant difference was found between the two groups in non-han Chinese (P＜0.05), the pooled OR(95%CI) value of G vs. C was 0.65 (0.52-0.83), while there was no significant difference between the two groups in the Han Chinese women (P＞0.05), the pooled OR(95%CI) value of G vs. C was 1.15 (0.91-1.45). Conclusions: rs266729 (-11377C/G) of adiponectin gene in non-han Chinese pregnant women was associated with GDM. The sub-allele gene G of this site was a protective gene, which would be of some value in the prevention and diagnosis of GDM.

Key words: Gestational diabetes mellitus, Adiponectin;, rs266729(-11377C/G), Polymorphism, Meta-analysis, Case-control studies