Abstract: Pre-eclampsia (PE) is a pregnancy-specific disease characterized by multiple organ and system damage, which seriously threatens the life of pregnant women and perinatal infants. Because of the unclear pathogenesis and rapid progress in clinical manifestations, there is no pertinence in prevention, treatment and management. The results of active termination of pregnancy and conservative treatment are not satisfactory. PE is still the main cause of maternal and neonatal mortality in developing countries. Current studies have confirmed that early intervention and treatment of PE can effectively reduce maternal and infant mortality and improve prognosis. In recent years, early prediction of the occurrence of PE through serological examination has become a research hotspot, including various cytokines and cyclic RNA, microRNAs, long non-coding RNAs and exosomes, etc. Some of them have achieved good predictive results. This article reviews recent advances in predictive markers of peripheral blood.

Key words: Pre-eclampsia, Biological markers, RNA, MicroRNAs, Exosomes