Abstract: Pre-eclampsia is a hypertensive disorder specific to pregnancy that remains a significant cause of maternal and neonatal morbidity and mortality, especially early onset pre-eclampsia in recent years. Low-dose aspirin has been clearly proved effective for pre-eclampsia prevention in foreign countries and it can decrease the development of pre-eclampsia and reduce the incidence of preterm birth and fetal growth restriction. However, some patients cannot achieve the expected effect and this phenomenon is called aspirin resistance (AR). AR also exists in studies related to the prevention of thrombosis by aspirin. The study of correlation between AR and genetic polymorphism has become a hot topic, including ABC transporter family genes, COX genes (COX-1 and COX-2), TXA2R, ADP receptor, GP receptor and interaction between genes. However，it is studied rarely in pregnant woman. We will expound the possible mechanisms of AR in cardiovascular disease from the perspective of gene polymorphism, to guide the use of aspirin in pregnant women and improve the pregnancy outcome.

Key words: Pre-eclampsia, Aspirin, Drug resistance, Genes, Polymorphism, genetic, Cardiovascular diseases