Abstract: Objective：High-intensity focused ultrasound（HIFU） ablation combined with gonadotropin releasing hormone agonists （GnRHa） was used in the treatment of adenomyosis, and its clinical application value was discussed. Methods：Patients of adenomyosis diagnosed and treated in the Department of Obstetrics and Gynecology of the First Hospital of Shijiazhuang from January 2015 to January 2018 was taken as the research objects. The cases were divided into two groups: the combined GnRHa group (n=41) was treated with HIFU ablation combined with GnRHa, and the simple HIFU group (n=48) was treated with HIFU ablation alone. The curative effect indexes of the two groups were compared after one year′s follow-up. Results：The lesion volume and uterine volume reduction rates in the combined GnRHa group were higher than those in the simple HIFU group (P＜0.05), and the hemoglobin level was higher ( P=0.044). The VRS score of dysmenorrhea in the combined GnRHa group was also better than that in the simple HIFU group ( P=0.018). There was no significant difference in serum CA125 level and incidence of adverse reactions between the two groups (P＞0.05). Conclusions：Compared with HIFU ablation alone, the combination of HIFU and GnRHa has better lesion volume reduction rate and uterine volume reduction rate, and hemoglobin level and dysmenorrhea symptoms improve better.

Key words: Adenomyosis, High-intensity focused ultrasound ablation, Dysmenorrhea, Gonadotropin releasing hormone agonists