Abstract: Ovarian cancer is a cancer with second highest morbidity and highest fatality of all gynecological malignant tumors all over the world. About 70% of the cases were diagnosed with advanced stage and the prognosis of them was poor. Surgery combined with chemotherapy is the standard treatment for ovarian cancer and lots of new drugs targeting different kinds of molecular pathways are under developing now. DNA damage response (DDR) plays a key role in maintaining genomic integrity by repairing DNA damage, and is regarded as a key to tumor drug resistance. Compared with normal cells, cancer cells usually have DDR defects and DNA damage repair disorder. Therefore, designing specific inhibitors targeting specific DDR defects in cancer cells provides a new direction for the treatment of ovarian cancer. This article reviews the mechanism and research progress of five kinase inhibitors of DDR pathway to identify a new way for the therapy of ovarian cancer.

Key words: DNA damage；, DNA repair；, Protein kinase inhibitors；, Ovarian neoplasms；, Poly (ADP-ribose) polymerase inhibitors；, Therapy