Abstract: Objective: To explore the characteristics of obesity and glycolipid metabolism in premature ovarian insufficiency(POI) patients. Methods: 102 POI patients with age 30.34±4.73 years and 68 healthy age-matched women(control group) with age 30.76±4.69 years, who came to Department of Gynecological Endocrinology in Beijing Obstetrics and Gynecology Hospital between January 2018 and June 2019, were recruited. Age and menstruation of these patients were recorded. Body height, body weight, waist circumference, hip circumference, basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), fasting plasma glucose (FPG), fasting insulin(FINS) and blood lipids(total cholesterol, triglyceride, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol) were measured. The indices between POI patients and control group were compared. Results: ①The hip circumference of POI patients was higher than control group (P=0.016). But there were no significant differences in other anthropometric indices between the two groups (P＞0.05). ②The comparison of the prevalence of overall obesity(27.4% vs. 23.5%) and abdominal obesity (33.3% vs. 33.8%) between POI patients and control group had no significant differences (P＞0.05). ③The level of TG, LDL-c and FINS in POI patients were higher than control group (P＜0.05). While there were no significant differences in TC, HDL-c, FPG and HOMA-IR between the two groups (P＞0.05). Conclusions: The prevalence of obesity in POI patients was similar to control group. While some of the glycolipid metabolism indices are different between POI patients and control group. So it is necessary to give a comprehensive assessment of POI patients in clinical work.

Key words: Premature ovarian insufficiency；, Obesity；, Glucose metabolism disorders；, Dyslipidemias；, Insulin resistance