Research Progress of Biomarkers Related to Endometriosis

doi:10.12280/gjfckx.20200561

Abstract

Abstract:

Endometriosis (EMs) is a common gynecologic disease and characterized as a chronic and hormone-dependent disease in which endometrial glands and interstitial tissue are implanted outside the uterine cavity. Despite decades of research, there are no sufficiently sensitive and specific signs and symptoms nor accepted biomarkers for the clinical definitively diagnosis of EMs, which hampers prompt diagnosis and treatment. To identify more effective non-invasive diagnostic biomarkers may provide a new thought for improving the clinical efficacy of EMs patients. Hormones, cytokines, chemokines, tumor-associated carbohydrate antigens, biomarkers related to epigenetic regulation and circulating endometrial cells involved in the chronic inflammation of EMs have been extensively studied in the pathogenesis of EMs, but currently no one can be a specific biomarker for EMs. It is of great significance to find highly sensitive and specific EMs biomarkers or a group of biomarkers as auxiliary methods for the diagnosis and monitoring of EMs. With the development of molecular biology and bioinformatics methods, screening approach using high-throughput technologies is expected to discover specific molecular markers related to this disease. This article reviews the latest research progress of EMs-related biomarkers.

Key words: Endometriosis, Biomarkers, High-throughput screening, Diagnosis

JIANG Mei, YUE Wen-tao. Research Progress of Biomarkers Related to Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 5-9.

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