Abstract:

Recurrent pregnancy loss (RPL) is a common and important clinical manifestation of undifferentiated connective tissue disease (UCTD), while UCTD is a hidden and extremely important immunological etiology of RPL. UCTD patients have a significantly increased risk of RPL, and the risk of UCTD in the RPL population also increases. Therefore, obstetrician and gynecologist as well as rheumatologist should pay attention to the screening and diagnosis of UCTD in the RPL population, especially the symptoms and signs related to UCTD and the screening of antinuclear antibodies, anti-extractable nuclear antigen antibodies, antiphospholipid antibodies and so on. For RPL patients diagnosed with UCTD, they should be referred to the rheumatology department during the pre-pregnancy period and standardized immune intervention therapy should be given to make sure they have stable immune status before pregnancy. Obstetrician and gynecologist as well as rheumatologist should carry out multidisciplinary cooperation to participate in the standardized monitoring and management of patients with both UCTD and RPL during their pregnancy, delivery and postpartum period, which will reduce the incidence of RPL and the adverse pregnancy outcomes and the risks of recurrence and progression of UCTD disease, ensure the safety of mother and child at the same time.

Key words: Embryo loss, Connective tissue diseases, Autoimmunity, Antibodies,antinuclear, Pregnancy, Diagnosis