Oxytocin Exposure during Labor and Risk of Postpartum Hemorrhage

doi:10.12280/gjfckx.20201041

Abstract

Abstract:

Postpartum hemorrhage is still one of the main causes of maternal death. Some studies have confirmed that oxytocin administration during labor is associated with a higher risk of postpartum hemorrhage, especially when the dose used during labor is high, the duration of time is long, or the woman does not receive active management in the third stage of labor. The desensitization sequence in oxytocin receptors is one of the pathophysiologic hypotheses, and clinically this can manifest as a reduction in oxytocin-induced contractility, resulting in uterine atony and postpartum hemorrhage. This paper reviews the research progress of the association between oxytocin during labor and risk of postpartum hemorrhage, so as to contribute to the establishment of a reasonable oxytocin administration and decrease the incidence of postpartum hemorrhage secondary to uterine atony.

Key words: Postpartum hemorrhage, Oxytocin, Receptors,oxytocin, Uterine inertia, Therapy

ZHAO Ying, CHANG Ying, YOU Xin, CHEN Xu. Oxytocin Exposure during Labor and Risk of Postpartum Hemorrhage[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 486-489.

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