Research Progress of Histone Methylation Modification in Endometrial Carcinoma

doi:10.12280/gjfckx.20220438

Abstract

Abstract:

Endometrial carcinoma is a malignant tumor of endometrial epithelium. Factors such as estrogen stimulation, obesity, diabetes, hypertension and non-pregnancy are high risk factors for its development. Recent studies have found that epigenetic modification also plays an important role in endometrial carcinoma. With the deepening of the research on histone methylation modification in endometrial carcinoma, more and more studies have found that histone methylation modification has complex biological behavior as an important part of gene transcription. Histone methylation-related enzymes are closely related to the occurrence of cancer. They may reprogram downstream genes by regulating histone methylation of promoters, enhancers, exons, repeats and other gene structures, thus playing an important role in the occurrence, development and prognosis of endometrial carcinoma. In the future, we may be able to regulate the biological behavior of genes by targeting histone methylation-related enzymes to better prevent and treat endometrial carcinoma.

Key words: Histones, Methylation, Epigenomics, Histone methyltransferases, Histone demethylases, Endometrial neoplasms

WEN Xin, WANG Bo, MA Xiao-xin. Research Progress of Histone Methylation Modification in Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 1-5.

Figures/Tables 2

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