Research Progress of LncRNA HOTAIR in Gynecological Malignant Tumors

doi:10.12280/gjfckx.20250334

Abstract

Abstract:

With the rapid development of high-throughput sequencing technology, the role of long non-coding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in gynecological malignant tumors has been gradually revealed. Studies have shown that HOTAIR is generally highly expressed in cervical cancer, ovarian cancer, and endometrial cancer, and is closely related to tumor progression, metastasis, and drug resistance. HOTAIR participates in the processes of tumor proliferation, invasion, metastasis, and drug resistance by regulating signaling pathways such as Wnt/β-catenin, transforming growth factor-β (TGF-β)/epithelial-mesenchymal transition (EMT), Notch, and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt). In addition, its genetic polymorphisms (such as single nucleotide polymorphisms) are closely related to the susceptibility of gynecological malignant tumors. Its characteristic of regulating microRNA function as a competing endogenous RNA (ceRNA) further highlights its key role in tumor molecular regulation. HOTAIR can not only serve as a potential molecular marker for the diagnosis and prognostic evaluation of gynecological malignant tumors, but may also become an important target for future individualized treatment strategies.

Key words: RNA, long noncoding, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms, Drug resistance, neoplasm, Signal transduction, Cell proliferation, HOTAIR

ZHOU Ling-ling, SONG Jian-dong, Sarina . Research Progress of LncRNA HOTAIR in Gynecological Malignant Tumors[J]. Journal of International Obstetrics and Gynecology, 2025, 52(5): 481-485.

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