Abstract: Objective：Study the expression of reversion-inducing cysteine-rich protein with Kazal motifs（RECK） and
matrix metalloproteinase-9（MMP-9） in different endometrial tissues and study their roles of invasion and metabasis in endometrial carcinoma. Methods：The expression of RECK and MMP-9 were detected in 42 cases of endometrial carcinomas， 15 cases of atypical hyperplasia and 26 cases of proliferative endometrium by S-P immumohistochemical technique. Results：Compared with atypical hyperplasia and proliferative endometrium groups，the positive rate of RECK protein in endometrial carcinoma was significantly lower（χ2=9.307，P＜0.05）and the positive rate of MMP-9 protein was obviously higher（χ2=11.438，P＜0.05）. There existed obviously negative correlation between the expressions of RECK and MMP-9（P＜0.01）.In endometrial carcinomas; the positive rate of RECK protein was positively related to FIGO stage，histologic grade and depth of myometrial invasion（P＜0.05）.However，the expression rate of MMP-9 protein did not correlate with
lymphatic metastasis，but it correlated with FIGO stage，histologic grade and depth of myometrial invasion（P＜0.05）.
Conclusions：RECK and MMP-9 may play important roles in the invasion and metastasis of endometrial carcinoma.

Key words: Endometrial neoplasms, Carcinoma, endometrioid, Membrane glycoproteins, Matrix metalloproteinase9, Neoplasm invasiveness