Abstract: Endometrial carcinoma（EC） is one of the most common malignant female genital carcinomas，and the incidence has been increased recently. Although it occurs mainly in the postmenopausal women，there are still 25% patients are premenopausal and 3%-14% patients are below 40 years old. Nevertheless，the standard surgical treatment is associated with the loss of their ability to fertility and the endocrine function of the ovaries among young women，which seriously affect the quality of their life. Nowadays，to preserve the fertility for the younger EC patients，the long-term use of high-dose progesterone is the main therapy of atypical endometrial hyperplasia and EC. However，progesterone resistance appears in many cases during the different stages，which reduces the effect of hormone therapy and influences the patients′ prognosis. Therefore，the further study of progesterone resistance and sensitization mechanisms is of great significance to improve the curative effect and preserve the fertility and endocrine function for the early stage EC patients. This article reviewed the progesterone resistance mechanisms and sensitizing ways of EC.

Key words: Endometrial neoplasms, Progestins, Progesterone, Therapy