Abstract: Number is origin of things，as everything in the world is created and expressed by numbers. I Ching：the Book of Changes，a masterpiece of Chinese traditional culture fundamental for all books and thoughts，which illustrates numbers as its core content，representing deep methodology and far reaching prospective towards universe，has a great impact on medical sciences. Digital medicine，as a new school of science crossing over information technology，medical sciences and many others，is thriving so as to make clinical practice more individualized，accurate，minimally invasive and remote. Linking the Book of Changes with digital sciences in combination therefore will enrich medical thoughts，improve medical values，and facilitate team buildup.

Key words: Book of Changes, Philosophy, Digital medicine, Humanities