Abstract: MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression in posttranscriptional level, miRNAs are involved in a variety of biological processes such as cell cycle regulation, differentiation, growth, metabolism and aging. miR-155 is one of the most studied miRNA, which is expressed in many human cancers. Recent studies have shown that the expression profiling of miR-155 shows evidently abnormal in ovarian cancer, cervical cancer and endometrial cancer which indicated that miR-155 might play an important role in regulate the occurrence and development of gynecological tumors. Here is to summarize the expression of miR-155 in ovarian cancer, cervical cancer and endometrial cancer and its significance in the early detection, clinical diagnosis, treatment and prognosis of tumour, as well as their research status in gynecologic malignant tumor.

Key words: MicroRNAs, Genital neoplasms, female, Uterine cervical neoplasms, Endometrial neoplasms, Ovarian neoplasms