Abstract: Objective：To investigate the role of APC gene inactivation in the occurrence and development of ovarian cancer. Methods：Databases such as PubMed, EMBase, Web of Science, and CNKI data were searched. Related literatures were published from January 1, 2000 to December 31, 2014. Only randomized controlled trials were included. The quality of the included studies were assessed by Newcastle-Ottawa Scale(NOS). Stata 11.0 software was used for statistical analysis such as OR value，heterogeneity and publication bias. Results：Nine studies, with 641 ovarian cancer patients and 377 controls were included in the Meta-analysis. Statistical results shows that the pooled odds ratio was 6.19 (95%CI: 4.08-9.41, P=0.000) in the case group versus the control group under fix effects model. The pooled odds ratio was 5.88 (95%CI: 3.662-9.450, P=0.000) in the cancer group versus the normal group under fix effects model. The pooled odds ratio was 6.99 (95%CI: 3.12-15.64, P=0.000) in the cancer group versus the benign tumor group under fix effects model. Conclusions：This analysis suggests that APC gene methylation had an association with ovarian cancer.

Key words: Ovarian neoplasms, Genes, APC, DNA methylation, Meta-analysis