Abstract: Premature ovarian failure（POF） refers to failure of follicle function which is caused by a variety of causes. About eighty percentages of POF belongs to idiopathic POF. Therapy of POF is very tricky. In recent years，stem cell therapy has obtained some achievements in the restoration of ovarian function in animal experiments at home and abroad. These achievements bring hope in aspect of recovery of ovarian function and fertility for patients with POF. Stem cell includes embryonic stem cells and adult stem cells. Study in embryonic stem cell therapy is restricted because of ethical controversy. The adult stem cell therapy includes germline stem cell therapy，bone marrow mesenchymal stem cell therapy，fetal mesenchymal stem cells therapy. Stem cells may differentiate into oocytes or inhibit follicle apoptosis through paracrine to restore damaged ovaries. This article mainly reviews research progress about stem cell therapy of POF.

Key words: Ovarian failure, premature, Stem cells, Embryonic stem cells, Adult stem cells