Abstract: SOCS3 is the suppressor of Cytokine Signaling 3；has been characterized as a regulator in the cytokine signaling pathway，which has a role in a variety of cells and cytokines. And it is the crucial effector in inflammation and apoptosis. During pregnancy there are lots of cytokines in the maternal-fetal unit of microenvironment. Cytokines involve in embryo implantation and the formation of placenta，fetal growth，childbirth，and so on，are controlled exactly by various factors，that contain a stable state conductive to the normal pregnancy. SOCS3 as a cytokine signal transduction regulator involve in the process of pregnancy and childbirth. Abnormal expression of SOCS3 is related to the occurrence and development of miscarriages，premature delivery，gestational hypertension，gestational diabetes，and other pregnancy sickness. An in-depth study of SOCS3′s role in diseases of pregnancy has provided a theoretical basis for the pregnancy-associated disease diagnosis and treatment.

Key words: Suppressor of cytokine signaling, Cytokines, Signal transduction, Pregnancy