Abstract: Objective：To evaluate the efficacy and safety of the combined oral contraceptive（COC） in the treatment of primary dysmenorrheal. Methods：Medline，Embase，The Chinese Biomedical Database（CJFD） and Chinese science and technology journal full-text database（CSJD）. All of the included studies were evaluated by Cochrane Handbook， homogenous studies were analyzed by Revman5.1.1 software. Results：Eight studies were included. Compared with placebo group，the COC group had a statistically significant in MDQ score（MD=2.7，95%CI：0.92-4.48，P=0.003） and VAS score（MD=
0.87，95%CI：0.54-1.21，P＜0.000 01）， The COC group has no statistically significant in adverse effect（OR=1.13，95%CI：0.76-1.68，P=0.54）. Conclusions： The COC can significantly reduce the pain score of the patients of primary dysmenorrheal，and it to be worthy of clinical application. But there is limited studies and the measure or index of these studies are different， so we look forward to more high quality studies to further prove the effectiveness of the COC.

Key words: Dysmenorrhea, Contraceptives, oral, combined, Meta-analysis, Database