Abstract: Oral anticoagulation medicine may cause women with heavy menstrual bleeding and changing their blood system，and with the characteristics of gynecology and gynecological surgery，it is a difficult clinical problem in gynecological surgery.When there is an operation，the doctor should balance individual risk for thromboembolism and bleeding. How to use anticoagulator and to select proper time is crucial to successful. Therefore，it is important and clinical significance in preoperative evaluation and perioperative management in gynecological surgery. This article discussed the application of the anticoagulant therapy in the gynecological clinical treatment.

Key words: Anticoagulants, Heparin, low-molecular-weight, Perioperative care, Gynecological surgical procedures, Postoperative complication