Abstract: Metabolic syndrome contains several metabolic disorders with insulin resistance as its pathophysiological basis. Epidemiological studies show that not only metabolic syndrome， but also metabolic syndrome related obesity， diabetes and hypertension which characterized with insulin resistance are all risk factors of endometrial carcinoma. At the state of insulin resistance， circulating insulin levels will increase. As a result， insulin promotes the development of endometrial carcinoma directly through the activation of its signaling pathway and indirectly through the up-regulation of the blood estrogen levels. Moreover， in the development of insulin resistance， the development of endometrial carcinoma is probably promoted simultaneously by some adipocytokines. Taken together， insulin resistance is a bridge related endometrial carcinoma with metabolic syndrome. Treatment targeting insulin resistance may serve as therapeutical purpose for inhibiting the development of metabolic syndrome related endometrial carcinoma.

Key words: Endometrial neoplasms, Metabolic syndrome X, Insulin resistance, Diabetes mellitus