Abstract: Objective： To detect the relationship between expression of E-cadherin and beta-catenin with endometrial carcinoma. Methods： A total of 65 specimens of endometrial carcinoma，38 normal endometrial tissues and 36 atypical hyperplasia endometrium tissues were evaluated by immunohistochemical technique with monocolonal antibodies against E-cadherin and beta-catenin. Results：The aberrant expression rates of E-cadherin and beta-catenin increased obviously from normal endometrial tissues，atypical hyperplasia endometrium tissues to endometrial carcinoma tissues（P<0.05）. Expression of E-cadherin was positively correlated with tumor grade，mymetrial invasion，surgical stage and lymphnode matastasis（P<0.05）. Expression of beta-catenin was also significantly correlated with tumor grade，surgical stage and lymphnode matastasis（P<0.05）. Conclusions： The aberrant expression of E-cadherin and beta-catenin was positively related to oncogenesis，invasion，metastasis and prognosis of endomentrial carcinoma. It should be considered to a certain extent as an index of malignant degree and prognosis of endomentrial carcinoma.

Key words: Cadherins, Beta catenin, Endometrial neoplasms, Immunohistochemistry