Abstract: S100A4 protein is a member of the calcium-binding protein family, which through the regulation of calcium and interaction with the target protein in the body, plays various biological functions, such as participating in the activities of the cell cycle, cell differentiation, tumor growth and the secretion of extracellular matrix activities in the process. In recent years, a large amount of studies indicate that S100A4 protein in a variety of tumors shows high expression and has a specific distribution of cells and tissues, and with tumor invasion and metastasis are closely related to the cause for concern. Here, we make a review of S100A4 for its molecular biological characteristics, the manners of regulating the metastasis of the tumor cells, and also its functions in gynecology tumors.

Key words: S100A4, Cervical carcinoma, Ovarian carcinoma, Enodmetial carcinoma