LIU Yan, BIAN Wei, XIAO Hong△

doi:10.12280/gjfckx.20220089

Abstract

Abstract:

CyclinE1(CCNE1) gene amplification is one of the most common copy number variations in high-grade serous ovarian carcinoma (HGSOC), with an amplification rate of about 20%. CCNE1 gene amplification not only participates in the early precancerous lesions of HGSOC and promotes the occurrence and development of malignant tumors, but also causes cell cycle disorder and chromosome instability, thus increasing platinum resistance and recurrence rate of HGSOC, and ultimately leading to poor chemotherapy effect and poor prognosis of patients. In order to improve the prognosis and quality of life of patients with CCNE1-amplified HGSOC, cyclin-dependent kinases 2(CDK2) small molecule inhibitors or poly (ADP-ribose) polymerase (PARP) inhibitors in combination with other drugs are used to treat CCNE1-amplified HGSOC in the absence of targeted drugs for CCNE1-amplified HGSOC. To a certain extent, it can effectively inhibit the proliferation of tumor cells and promote the death of tumor cells. Therefore, CCNE1 gene is expected to become a potential therapeutic target and prognostic biological indicator of HGSOC from the perspective of the influence of CCNE1 amplification on the early pathogenesis of HGSOC and the generation of platinum resistance, which is of great significance to improve the treatment and prognosis of patients.

Key words: Ovarian neoplasms, Cyclin E, Gene amplification, Drug therapy, Prognosis, High-grade serous ovarian carcinoma

LIU Yan, BIAN Wei, XIAO Hong. LIU Yan, BIAN Wei, XIAO Hong^△[J]. Journal of International Obstetrics and Gynecology, 2022, 49(3): 286-290.

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