Abstract: Amniotic fluid embolism（ＡＦＥ） is widely known as a disastrous rapid-progressing intrapartum complication. The incident ranges from 2/100 000 to 6/100 000. The mortality rate reaches 61%—86%. Neonatal survival is reported at 70%. We describe a case of severe AFE in our practice and review the relevant documents. A 33-year pluripara developed amniotic fluid embolism during labour. The mother identified as gestational anemia when came to our hospital with acute respiratory failure to be her initial symptom. A forceps delivery was performed. She showed extreme blood loss complicated by disseminated coagulopathy. A subtotal hysterectomy was performed due to approximately 3000 mL bleeding. Aggressive management was practiced with continuous transfusion of blood products. Haemodialysis was performed because of chronic renal failure after her being transmitted to ICU. The patient had been treated for 3 months and discharged from hospital with an improved condition and a survived baby without neurological damage. The patient receives dialysis regularly due to chronic renal failure.

Key words: Embolism, amniotic fluid, Caesarean section, Cardiopulmonary resuscitation, Renal failure