Abstract: Long non-coding RNA（lncRNA） is a class of RNA with the length of more than 200 bases. Previously，lncRNA molecules are generally considered as byproducts formed during the transcription of the genome，and are defined as transcriptome "background noise" without biological functions since these special RNA molecules do not participate in the encoding of certain proteins. However，in recent years，an increasing number of studies have found that thousands of genes in mammalian genomes can transcribe into lncRNA. Then，after the mature processing，lncRNA molecules play a key role in animal embryonic development，regulation of gene expression and disease progress. Present studies have confirmed that the expression levels of specific clusters of lncRNA molecules change significantly during different periods of the disease progression in a variety of human tumor diseases. In gynecological malignancies，the changes of lncRNA expression levels and its regulatory roles in the development of the disease through the upstream or downstream targeting molecules have been reports in many studies. This review conclude the latest progress of this area.

Key words: Long non-coding RNA, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms