Abstract: Objective：To analyze the expression of SULT1E1，ERα，ERβ，PRA and PRB protein in uterine sarcoma in order to find their clinical significance. Methods：The immunohistochemical method was used to detect the expressions of SULT1E1，ERα，ERβ，PRA and PRB in 31 cases of endometrial stromal sarcoma，15 cases of leiomyosarcoma tissues，10 cases of uterine leiomyoma tissues and 10 cases of normal myometrium tissues far away the wrapping membrane of myoma. Results：①The positive rate of SULT1E1 protein in endometrial stromal sarcoma and leiomyosarcoma tissues is significantly lower than that in normal myometrium tissues（P＜0.016 7）. ②The positive rate of ERα protein in endometrial stromal sarcoma and leiomyosarcoma tissues is significantly lower than that in uterine leiomyoma（P＜0.016 7）. ③The positive rate of PRA protein in leiomyosarcoma is significantly lower than that in uterine leiomyoma（P＜0.016 7）. ④In endometrial stromal sarcoma tissues， SULT1E1 had negative correlation with ERα，PRA and PRB（rs=-0.463，P=0.009；rs=-0.389，P=0.031；rs=-0.421，P=0.018，respectively），and had no correlation with ERβ（rs=0.018，P=0.925）. ⑤In endometrial stromal sarcoma tissues, ERα had positive correlation with PRA and PRB（P＜0.01）. Conclusions：The diminution or deletion of SULT1E1 protein expression relates to the development uterine sarcoma；SULT1E1 has significantly negative correlation with ERα, PRA and PRB in endometrial stromal sarcoma，which may influence the development of endometrial stromal sarcoma.

Key words: Sarcoma, Uterine neoplasms, Estrogen receptor alpha, Estrogen receptor beta, Receptors, progesterone, Transferases, Immunohistochemistry