Abstract: Endometriosis（EMs） is an estrogen-dependent disease characterized by extrauterine implantation and ectopic growth of endometrium and it’s a common disease of women of reproductive age. The invasive implantation of ectopic endometrium is a complicated procedure，which involves in multiple factors and a few signaling pathways and mitogen activated protein kinase signaling pathway plays the important role. The signaling regulation between MAPK pathway and ERs is intimate. The interaction between MAPK and ER plays important roles in stimulating the proliferation of endometriotic cell，the production of inflammatory factors and the neovascularization.On this basis，this article reviewes the relationship between MAPK signal pathway and the pathogenesis of endometriosis to better understand the mechanism of endometriosis with new ideas.

Key words: Endometriosis, JNK mitogen-activated protein kinases, p38 mitogen-activated protein kinases, Estrogens, Signal pathway