Abstract: Preeclampsia is a severe obstetrical complication，accompanying by maternal irreversible multiple system
damage and fetal intra-uterine growth restriction. Once diagnosed with preeclampsia，the only cure was to terminate pregnancy and deliver the placenta. Although there are many hypotheses in the mechanisms of preeclampsia，the etiology of preeclampsia is still unclear. Different from genetics，epigenetics is to elucidate inheritable changes of organism without change of genomes sequence. The role of epigenetic factors in the etiology of PE is poorly characterized. Certainly，the main analyzed epigenetics factors in preeclampsia are DNA-methylations，miRNA and gene imprinting.

Key words: Pre-eclampsia, Epigenesis, genetic, DNA methylation, MicroRNAs, Genomic imprinting