Abstract: Microparticles are cell fragments that derived from cell activation and/or apoptosis. Cycling microparticles can serve as vehicles carrying and transporting varieties of proteins and frangements of DNA or RNA. Microparticles can promote thrombus formation， mediate pro-inflammatory effects and may cause endothelial dysfunction directly. Most kinds of cells in human can produce microparticles. Studies have found a much higher formation of syncytiotrophoblast microparticles in preeclampsia women than normal pregnancies. Studies in vitro also found that the lipid levels in microparticles can impact their abilities of inhibiting proliferation and promoting apotosis in human umbilical vein endothelial cell. The higher lipid levels， the stronger abilities to inhibit proliferation and promote apoptosis. In another study， volunteers intaking high fat diet have higher level of total circulation microparticles than normal diet.

Key words: Pre-eclampsia, Chylomicrons, Lipoproteins, Endothelial cells