Research Advances on Protein Post-Translational Modification in the Pathogenesis of Preeclampsia

doi:10.12280/gjfckx.20230795

Abstract

Abstract:

Protein post-translational modification refers to a series of covalent modifications that occur after protein translation. These modifications can regulate the structure and function of protein, thereby, affecting the development and progression of various diseases. Preeclampsia is a pregnancy-specific syndrome, but the cause of it is still not fully understood. Recent investigations suggest that post-translational modifications of proteins may play a crucial role in the pathogenesis of preeclampsia. In this article, we review the progress of common protein post-translational modifications, such as phosphorylation, acetylation, glycosylation, ubiquitination, and lactypation, in the pathogenesis of preeclampsia, which will provide new directions for exploring the pathogenesis of preeclampsia and for improving diagnostic and therapeutic measures.

Key words: Pre-eclampsia, Protein processing, post-translational, Ubiquitination, Acetylation, Glycosylation, Phosphorylation, Lactylation

CHEN Jia-ying, FENG Ya-ling. Research Advances on Protein Post-Translational Modification in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 1-4.

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