The Role of Exosomes from Different Sources in Pathogenesis and Treatment of Preeclampsia

doi:10.12280/gjfckx.20230727

Abstract

Abstract:

Preeclampsia (PE) is one of the most serious complications of pregnancy, which threatens the lives of pregnant women and fetuses. However, the pathogenesis and effective treatments of PE are still unclear. Exosomes are membrane vesicles secreted by cells and contain a variety of components. They have different biological functions, such as cell-to-cell communication and serving as biomarkers, which may provide new models for early screening and treatment of PE. And exosomes of different origins (especially placenta- and mesenchymal stem cell-derived exosomes) can play different roles in PE. For example, placenta-derived exosomes are involved in immune regulation processes in PE, while mesenchymal stem cell-derived exosomes promote endothelial cell proliferation and migration. In addition, the relationship between PE and exosomes from other sources still needs to be clarified. This article reviews the research of exosomes from different sources in the pathogenesis and treatment of PE.

Key words: Exosomes, Pre-eclampsia, Placenta, Biomarkers, Therapy

MENG Fei, LIU Hui-qiang. The Role of Exosomes from Different Sources in Pathogenesis and Treatment of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 10-14.

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