Journal of International Obstetrics and Gynecology ›› 2013, Vol. 40 ›› Issue (2): 108-111.

• 综述 • Previous Articles     Next Articles

Progress of the Influence Factors of Angiogenesis in Ovary Transplantation

WANG Lin,YING Ying-fen,XU Jian   

  1. Women′s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-04-15 Online:2013-04-15
  • Contact: XU Jian

Abstract: Advances in the diagnosis and treatment has gradually increased the long-term survival rates of female cancer patients. Unfortunately,operation and chemo/radiotherapy can result in ovarian failure. Besides,part of the female patients is not suitable for ovulation in vivo. Therefore ovarian transplantation is being a promising research. The major objective of ovarian transplantation is to preserve fertility by minimizing loss of primordial follicles and oocytes and optimizing follicular development. Transplanted fragments of the ovaries are prone to ischemic damage during the early period after transplantation. Thus, reducing the duration of ischemia and accelerating graft revascularization is the urgent challenge. The angiogenesis of the ovarian tissue is influenced by the size of graft,the site of transplantation,freeze-stored or not,the usage of gonadotropin,VEGF, surgical wounds and so on. This review will have a comprehensive introduction into the influence factors of angiogenesis which provide the reference for improving the survival rate of graft and follicles development.

Key words: Ovary, Transplantation, autologous, Transplantation, heterologous, Chorionic gonadotropin