Abstract: Ovarian cancer，the most lethal gynecological cancer，is a serious threat to women′s health and lives. Various molecular changes have been identified in ovarian cancer. The change of epigenetics is closely related with the carcinogensis in human and tumor suppressor gene DNA methylation is a common phenomenon in ovarian cancer. DNA methylation is one of the main way of epigenetic mechanisms of transcription control. The new reports indicate that aberrant expression of genes result from abnormal DNA methylation of specific genes and an important effect with the carcinogenesis and development of ovarian cancer. Especially the hypermethylation of CpG island in the promoter region may contribute to the loss of tumor suppressor genes such as BRCA1 and RASSF1A so on.We summarized the research progress of DNA abnormal methylation in ovarian cancer , which would be helpful to the molecular mechanisms in early diagnosis，therapy and prognosis of ovarian cancer.

Key words: Ovarian neoplasms, DNA methylation, Genes, tumor suppressor, Genes, BRCA1