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15 February 2013, Volume 40 Issue 1
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Research Progress of PIGF，sVEGFR-1，sEng’s Regulation of Blood Vessel Balance with Stillbirth ZHANG Ze-hua;XU Duo;WANG Chen-hong 2013, 40 (1):  3-6.  Abstract ( 1324 )   PDF (415KB) ( 5127 )   Angiogenic factors and anti-angiogenic factors have been studied in many areas. Now，they have become a hot spot in the pathological obstetrics，many researches are on the preeclampsia in maternal plasma，but the role of them in stillbirth is still ralely reported. This paper mainly discusses the clinical etiology of stillbirth，the significance of PIGF、 sVEGFR-1、sEng′s change and the reasons for stillbirth of amniotic fluid and maternal serum of endothelial growth factor receptor-1、placental growth factor and soluble endoglin sEng concentration. We make a detailed study of the relationship between changes of anti-angiogenic and anti-angiogenic factor and the occurrence of stillbirth，open up new ideas for the etiology and pathogenesis of stillbirth. Related Articles | Metrics

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Influence of Fetal Microchimerism on the Maternal Body YAN Hua-ying;WANG Chen-hong 2013, 40 (1):  7-9.  Abstract ( 2043 )   PDF (411KB) ( 5487 )   Fetal microchimerism（FMC）resides widely in woman′s body during pregnancy. Although the exact mechanism of FMC is not clear，in recent years several studies have been made which illustrate the influences of FMC on the maternal body.The abnormality of FMC may be related with complications of pregnancy and adverse pregnancy outcome，such as preeclampsia. FMC are also implicated in the pathogenesis of autoimmune diseases which usually occur to women and ameliorate during pregnancy. It has also been proposed that genetically disparate FMC may protect mother from some cancers，because it can offer new alleles for mother. FMC are often found at sites of maternal injury and may play an active role in regeneration of tissue injury. This article will summarize the influence of FMC on the maternal body. Related Articles | Metrics

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Update on Diagnosis of Cytomegalovirus Infection During Pregnancy SHEN Feng-xian;LYU Shi-ming 2013, 40 (1):  10-13.  Abstract ( 1596 )   PDF (482KB) ( 5132 )   Human cytomegalovirus（CMV） is the most common pathogene of congenital viral infection. Pathological changes of placenta resulted from CMV infection of placenta combined with cytopathy caused by fetal infection induce serious birth defects， which will be severe challenges to aristogenesis rearing of the state. For a long time， scholars in different countries have been working together to prevent and control symptomatic congenital CMV infection. Both primary and secondary maternal infection can cause intrauterine transmission. CMV serological screening is important for identifying high risk pregnancy. HCMV-specific IgG avidity assay provides more information besides IgG and IgM testing. Once we prove maternal CMV infection， fetal prognosis assessment is most critical. Amniotic fluid CMV-DNA detection and imaging studies could be used to diagnosis of intrauterine infection and fetal prognosis. Related Articles | Metrics

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Progress of Prenatal Ultrasonographic Evaluation of Fetal Anemia CHAI Yi-qing;ZHANG Zhi-kun 2013, 40 (1):  14-16.  Abstract ( 1435 )   PDF (468KB) ( 5151 )   Prenatal prediction of fetal anemia is recognized as a important contributor to guiding the clinical intervention，reducing the perinatal mortality rate and improving the quality of perinatal medicine. Traditional method of prenatal diagnosing fetal hemolytic anemia belongs to the invasive detection，which significantly increased the risks of maternal and fetuses.Recently，there are great progress and development in prenatal diagnosis for fetal anemia in accordance with application two-dimensional，three-dimensional and Doppler ultrasound. More research indicators include thickness and volume of placental，middle cerebral artery peak velocity，fetal cardiovascular circulation，splenic artery peak velocity，free segment of umbilical artery，umbilical vein diameter，umbilical artery pulsatility index，as well as intrahepatic umbilical vein peak velocity，velocity of ductus venosus. In the numerous index in ultrasound，fetal MCA-PSV is the best markers in sensitivity and specificity，combination of multiple indicators will improve the accuracy of diagnosis. Related Articles | Metrics

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Advances of OCT4 in Obstetrics and Gynecology ZHANG Wei-wei;CHEN Qing 2013, 40 (1):  17-20.  Abstract ( 1699 )   PDF (462KB) ( 5081 )   Octamer-binding transcription factor 4 （OCT4） is a member of the Pit-Oct-Unc（POU） transcription factor family，which is expressed in embryonic stem（ES） cells，germ cells，embryonal carcinoma（EC）cells，germ-cell tumors and known to play a crucial role in the maintenance of stem cell pluripotency，self-renewal and tumor malignant behavior as a marker of stem cells. Meanwhile，OCT4 also regulates the multipotent differentiation in the embryonic development. In recent years，an increasing number of persons committed to the research about stem cell theory and OCT4 in different disciplines. This paper provides an overview about OCT4 research in obstetrics and gynecology. Related Articles | Metrics

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Research Progress of Human Ovarian Tissue Xenograft Model YING Ying-fen;WANG Lin;XU Jian 2013, 40 (1):  21-23.  Abstract ( 1354 )   PDF (510KB) ( 5150 )   Recently， progress of cancer treatment obviously improved survival rate of young cancer patients. Unfortunately，side effects of long-term anti-neoplastic therapy made female patients at high risk of premature ovarian failure and infertility. For some female patients who have no childbearing yet，it’s important for their fertility preservation. Xenotransplantation not only avoid reintroducing tumor cells into patients， but also provide the possibility of preserving young female’s fertility. This review will have a comprehensive introduction into the source of human ovarian graft，culture temperature， pre-treatment procedure before xenograft surgery， xenograft site， selection of receptors and processing， application of gonadotropins and so on. Related Articles | Metrics

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Insulin Resistance Performance of Animal Models of Polycystic Ovary Syndrome DU Dan-feng;LI Xue-lian 2013, 40 (1):  24-26.  Abstract ( 1554 )   PDF (558KB) ( 5118 )   Polycystic ovary syndrome（PCOS），whose etiology is still not clear，is a common endocrine disorder of reproductive-age female. More and more researches indicate that hyperinsulinemia and insulin resistance play an important role in the occurrence and development of PCOS in recent decades. Usually，we use a variety of animal models for the study of it’s pathogenesis and therapeutic effect. Common polycystic ovary animal model manufacturing methods include androgen， androgen+hCG， estrogen method， letrozole method， insulin + hCG method， progesterone + hCG method， this paper summarizes the insulin resistance performance of common animal models of polycystic ovary syndrome ， and to explore which model is more suitable for the study of insulin resistance in the occurrence and development of the disease. Related Articles | Metrics

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Significance of Stem Cells in the Pathogenesis of Endometriosis YU Cong-xiang;SONG Jing-hui 2013, 40 (1):  27-30.  Abstract ( 1369 )   PDF (616KB) ( 5122 )   The pathogenesis of endometriosis（EMs） which is multifactorial remains unclear. Studies have proved there are stem/progenitor cells（SC） in endometrium，including endometrium-derived and bone marrow-derived SC，which induce the periodic regeneration of endometrium. More and more studies attempt to identify specific markers of SC in order to isolate and characterize endometrial SC. And they put forward the endometrial stem cell hypothesis of EMs，which consider EMs is induced by abnormal proliferation and differentiation of SC. All kinds of stem cells provide the“seeds”，while menstrual reflux， estrogen therapy and the microenvironment provide the“soil”. Once the seeds meet the soil，EMs will occure. This hypothesis uncovers a new era of the pathogenesis and clinical research on EMs. Related Articles | Metrics

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Recent Advances in Relation of Hypoxia and Endometriosis LU Ze-chun;LI Ya-li 2013, 40 (1):  31-34.  Abstract ( 1323 )   PDF (629KB) ( 5128 )   Endometriosis is a relatively common condition in women of reproductive age. the pathogenesis and development of endometriosis are still poorly understood. The theory of retrograde menstruation with implantation of endometrial fragments，in conjunction with peritoneal factors to stimulate cell growth is the most widely accepted. Immunological factors and angiogenesis also influence the pathogenesis of endometriosis. Endometriosis lesions are inevitably exposed to ischaemia and hypoxia microenvironment that could adversely influence the initiation and progression of the disease. The present review highlights the fact that hypoxia play an important role in genesis of endometriotic lesions. hypoxia is connected with angiogenesis and apoptosis and immune injury of the endometriotic lesions. The effects of hypoxia can be protected by estrogen. Certain proangiogenic and antiangiogenic plant components have been used in traditional Chinese medicine （TCM） in healing endometrisis successfully. This review also explores the prospects of hypoxia on TCM therapies，which may be a new idea for endometriosis drug treatments. Related Articles | Metrics

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The Reproductive Healthcare of Women with Systemic Lupus Erythematosus ZHANG Huan-xiao;XU Yan-wen 2013, 40 (1):  35-39.  Abstract ( 1458 )   PDF (628KB) ( 5092 )   Systemic lupus erythematosus（SLE） is an autoimmunologic disease that most commonly happens in women of reproductive age. Exposure to estrogen is one of the reasons that may trigger or aggravate lupus. On one hand， SLE itself as well as the treatment may cause ovarian malfunction， premature ovarian failure and osteoporosis. On the other hand， high estrogen status， such as pregnancy or hormonal supplement， may lead to relapse of SLE. As survival rate improves with the development of therapeutic measures，more and more women with SLE come to be faced with the need for pregnancy， assisted reproductive therapy or hormone replacement therapy， which brings up a potential risk of aggravating the disease. This essay aims at reviewing the reproductive healthcare of women with SLE from the aforesaid prospective. Related Articles | Metrics

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Research Progress in the Epidemiological Survey of Uterine Myoma NIU Jian-qing;CHEN Xing-wei;MI Ruo-ran 2013, 40 (1):  40-43.  Abstract ( 1351 )   PDF (639KB) ( 5225 )   Uterine myoma is the most common benign tumor of the female reproductive system，which is made up of smooth muscles and connective tissues. The exact etiologies that cause the uterine myoma are not well known. Because of it’s high morbidity and affect the quality of life， uterine myoma is a major cause of hysterectomy in many countries. In recent years， we have got some new cognitions in the etiology of uterine myoma， such as age，obesity， history of pregnancy and miscarriages， race， smoking， drinking， blood pressure and exercises， harmful environment and genetic factors and so on. These progress may play a guiding role in prevention and treatment. So we conduct a review of uterine myoma. Related Articles | Metrics

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Status and Development of Lymphedema Treatment After Gynecological Carcinoma Operation or Radiotherapy ZHANG Yan-hua;LIU Qing 2013, 40 (1):  44-46.  Abstract ( 1658 )   PDF (671KB) ( 5200 )   As an important complication after gynecological carcinoma operation and radiation， lymphedema is widely noticed in recent years， because of its high morbidity rate and refractory nature. According to the study on the morbidity rate of lymphedema， the patient′s age， surgical method and treatment differences were statistically significant. Medical treatments for lymphedema include some complex physical therapy methods， such as skin maintenance， massage， compression and movement under compression. Surgical treatments for lymphedema include tissue removal and drainage bypass surgery. By introducing clinical manifestation and treatment status of lymphedema， this thesis provides some reference to early diagnosis and treatment of lymphedema after gynecological carcinoma operation and radiation. Related Articles | Metrics

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Research Development of　Detection of HPV L1 Capsid Protein in Predicting Development of the Cervical Disease XIAO Qian;ZHANG Shu-lan 2013, 40 (1):  47-49.  Abstract ( 1544 )   PDF (685KB) ( 5300 )   Cervical cancer is the second most common tumor in gynecologic oncology，HPV L1 protein is the major capsid protein of HPV，and it′s expression is closely related to viral replication and early infection. Recent study shows that present screening method simultaneously unites HPV L1 capsid protein　detection may　enhances the accuracy for the screening cervical　disease　and　prediction of progression of lesions． This review is concentrated on update scientific nature and the usability　of the research for detection of HPV L1　capsid protein　in predicting the prognosis and development of cervical disease　a review，looking for the more reasonable screening flow，and choosing the different therapeutic schedule for different patients. Related Articles | Metrics

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Research Progress of the Risk Factors of Ovarian Cancer ZHAO Wen-hua;SONG Jing-hui 2013, 40 (1):  50-53.  Abstract ( 2061 )   PDF (736KB) ( 6027 )   Ovarian cancer is one of the most common femal reproductive malignancies. It holds high mortality because the etiology is unclear， most patients are diagnosed at advanced stages and advanced treatment effect is poor. Ovarian cancer and other malignant tumors are the same， although the exact reason of disease is not at all clear， many risk factors of ovarian cancer have been found by a large number of epidemiological studies. So studying these risk factors， closely observing，further researching and analysising high risk group who have precursor lesions of ovarian cancer， and taking some feasible prevention measures to block malignant behavior of precursor lesions of ovarian cancer. It has great clinical significance in early diagnosis and prevention of ovarian cancer. In recent years，many scholars at home and abroad commit in screening and prevention of risk factors of ovarian cancer，and they have made sure achievements. Related Articles | Metrics

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Updates in the Study of Autophagy in Ovarian Cancer BAO Ling-jie;YI Xiao-fang 2013, 40 (1):  54-56.  Abstract ( 1618 )   PDF (720KB) ( 5226 )   Autophagy is called“TypeⅡ Programmed Cell Death” in which the cell digests damaged organelles and molecules with lysosomal system and maintains energy cycling. The dysfunction of autophagy is related to cancer. Ovarian cancer is of great malignance. While most of patients are diagnosed with advanced stage and will eventually relapse，the 5-year survival rate is approximately 20%-25%. It is investigated that autophagy has some connection with the carcinogenesis， prognosis and treatment of ovarian cancer. Some autophagy-related genes such as Beclin 1 were shown downregulated in ovarian cancer tissue， while overexpression of PEA-15， an autophagy-related protein， was reported to be associated with longer survival rate in women with ovarian cancer， and thus to be a potentially promising prognostic biomarker. The role of autophagy in the management of ovarian cancer is still debating. This review aims to address the progression of autophagy in ovarian cancer. Related Articles | Metrics

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Advances in Study on Correlations Among Estrogen，Th17 /Treg with Ovarian Cancer QIU Jun-jun;HUA Ke-qin 2013, 40 (1):  57-60.  Abstract ( 1529 )   PDF (749KB) ( 5129 )   Ovarian cancer is one of the most sophisticated gynecological problems with undetermined etiology and high mortality， demanding prompt solutions. Although various hypotheses have been introduced previously， none of which can fully elucidate the pathogenesis of ovarian cancer. Recent researches have shown that the immune system is closely associated with neuroendocrine system in patients with ovarian cancer. Estrogen on hypothalamic-pituitary-ovarian axis and Treg、Th17 cells in internal immune environment lay in the same tumor microenvironment of ovarian cancer. Based on this， this review deals with the recent progress and circumstances on interrelations among estrogen、Th17 /Treg and ovarian cancer in order to broaden minds for further study from the perspective of neuro-endocrine-immunoregulatory network. Related Articles | Metrics

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Research Progress of DNA Abnormal Methylation in Ovarian Cancer GAO Gui-qin;LIN Wan-jun 2013, 40 (1):  61-63.  Abstract ( 1485 )   PDF (749KB) ( 5150 )   Ovarian cancer，the most lethal gynecological cancer，is a serious threat to women′s health and lives. Various molecular changes have been identified in ovarian cancer. The change of epigenetics is closely related with the carcinogensis in human and tumor suppressor gene DNA methylation is a common phenomenon in ovarian cancer. DNA methylation is one of the main way of epigenetic mechanisms of transcription control. The new reports indicate that aberrant expression of genes result from abnormal DNA methylation of specific genes and an important effect with the carcinogenesis and development of ovarian cancer. Especially the hypermethylation of CpG island in the promoter region may contribute to the loss of tumor suppressor genes such as BRCA1 and RASSF1A so on.We summarized the research progress of DNA abnormal methylation in ovarian cancer , which would be helpful to the molecular mechanisms in early diagnosis，therapy and prognosis of ovarian cancer. Related Articles | Metrics

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The Application of Nano Drug in the Targeted Treatment of Ovarian Cancer CHEN Jing-yun;HU Yue;ZHANG Qiong 2013, 40 (1):  64-66.  Abstract ( 1378 )   PDF (691KB) ( 5119 )   Ovarian cancer is one of the most common malignant tumors in women，the lethality is the highest in gynecological malignant tumors. Nano drug have high targeting property and slight adverse reaction，and it is becoming one of the hot spots in targeting treatment of ovarian cancer. The application of nano durg in the ovarian cancer includes targeted chemotherapy，targeted gene therapy，targeted radiation and so on. At present，the application of nano drug in ovarian cancer is still in the initial stage，but we believe that it will play an important role in the treatment of ovarian cancer. Related Articles | Metrics

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The Application of Diaphragm Resection in Late Stage of Ovarian Cancer LU Yan;YAO De-sheng 2013, 40 (1):  67-70.  Abstract ( 1732 )   PDF (751KB) ( 5174 )   Ovarian cancer is gynecological malignancy with the highest death rate from the disease.Due to the insidious nature of ovarian cancer， the majority of patients at time of diagnosis have progressed to stage Ⅲ or stage Ⅳ disease. Surgery is the main treatment of ovarian cancer， optimal cytoreduction is the independent factors affecting prognosis. Patients with advanced ovarian cancer often have disease invading the upper abdomen， most commonly， the diaphragm，about18%-42%. And the metastasis is also difficult to managed，leads to suboptimal cytoreduction with reducing survival rate。A number of surgical techniques are available to effect cytoreduction of diaphragmatic involvement by ovarian cancer。Diaphragm metastasis is not abstacle of optimal cytoreduction， and diaphragm resection is necessary procedure of cytoreduction. This Article is to describe the application of the technology in ovarian cancer. Related Articles | Metrics

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Periconceptional Exposure to Air Pollutants SO2，NO2 Associated with Birth Defects ZHENG Jin-yan;HUI Wu-li;LAN Xiao-xia;HOU Hai-yan;WANG Dan;CHEN Ya-qiong 2013, 40 (1):  71-74.  Abstract ( 1456 )   PDF (786KB) ( 5142 )   Objective：The aim of this study is to investigate the association between the exposure to air pollutions during maternal pregnancy and the risk of birth defects. Methods：A population-based case-control study was conducted to analysis the relationship between birth defects and air pollutants. The data of birth defects was collected from 20 hospitals in the six districts of Tianjin. The data used to be compared was also collected from the same hospitals during the same period. The data of the ambient pollutions was offered by Environmental Monitoring Centre of Tianjin（SO2，NO2）. The average density of the air pollutions per month was collected from January 2001 to December 2006 in the six districts of Tianjin. Results：①The exposure air concentration of NO2 in mother delivery of congenital heart diseases in the 3 months before pregnancy and the first trimester is higher than that of the control group. ②Exposure to NO2 during 3 months before pregnancy and periconceptional were positively correlated with limb shortening，while 3 months before pregnancy were positively correlated with multiple means or toe deformity. The concentration of NO2 in the first month of the pregnant will increase the risk of birth defect. There was no significant difference between air pollutant SO2 and birth defects. Conclusions：The concentration of NO2 in 3 months before and after the pregnant will increase the risk of birth defect. Air pollution could have an adverse effect on normal fetal development in early pregnancy. Related Articles | Metrics

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Clinical Observation of Efficacy of GnRHa Combined with Add Back Therapy in the Treatment of Advanced Endometriosis After Laparoscopic Operation FAN Bao-guang;REN Chen-chen 2013, 40 (1):  75-76.  Abstract ( 1497 )   PDF (802KB) ( 5160 )   Objective: To observe the therapeutic effects and safety of endocrine response of gonadotropin（hormone）- releasing hormone-analogue （GnRHa） combined with conjugated estrogen （CEE） and medroxyprogesterone acetate （MPA） in the treatment of advanced endometriosis after laparoscopic operation. Methods: Ninety-six cases of endometriosis after laparoscopic. Patients were randomly divided into three groups， single-agent group（33 cases）: in postoperative subcutaneous injection of triptorelin 3.75 mg， once every 4 weeks for 6 times; anti-plus group（32 cases）: after subcutaneous injection of triptorelinin 3.75 mg， once every 4 weeks for 6 times， since the fourth injection， we add conjugated estrogens 0.625 mg/d with medroxyprogesterone acetate 5 mg/d for 3 months; the control group （31 cases） without drug treatment. Results: Complete remission rate of clinical symptoms in single-agent group and add-back group was 90.9% and 93.8% respectively， significantly higher than 48.4% in control group（P ＜0.01）；cumulative relapse rates in single-agent group and add-back group were 3.0% and 6.2%，significantly lower than 33.3% in the control group（P ＜0.01）；the serum E2，FSH，LH concentration in single-agent group after treatment was significantly lower than that before treatment（P ＜0.01）. Conclusions: GnRHa combined with conjugated estrogen and medroxyprogesterone acetate is safe and effective in the control of low estrogen symptoms， reduce bone turnover， etc. Add-back therapy can reduce the side effects of GnRHa with unaffectting its efficacy. Related Articles | Metrics

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Compare of the Influence on Cervical Lesion Between Single and Multiple HPV Genotype Infection SUN Chong;ZHANG Li-qin;YUE Tian-fu 2013, 40 (1):  77-80.  Abstract ( 1979 )   PDF (773KB) ( 5232 )   Objective：To discuss the differences between the cervical lesions induced by single hr-HPV and multiple hr-HPV infection，by comparing the liquid-based cytology and biopsy pathological results of all the cases. Methods：Compare the probability of all the LCT and pathologic results. Compare the differences between the cervical lesions，which were induced by single hr-HPV and multiple hr-HPV infections. Results：①In all the infection cases，the most common age was from 20 to 49， and the incident rate went down along with the age increasing.②In all the infection cases，HPV16 was the most frequent type. ③In all the cases of high grade cervical lesions，HPV16 was the most frequent type.④Compare of the single hr-HPV and multiple hr-HPV infections，there were no significant differences between the cervical lesions. ⑤CINⅡ-Ⅲ lesions，which induced by pure hr-HPV infections were higher than mixed HPV infections，in opposition to low grade cervical lesions. Conclusions：①Compare with single hr-HPV infection，the cervical lesions，which induced by the multiple hr-HPV infections，is not obvious. ②Compare with single hr-HPV infections，the mixed HPV infections induced more low grade cervical lesions. Related Articles | Metrics

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Study on Human Papillomavirus Infection Among Women in Nanning BAI Hua;HUANG Ning;LIU Ji-xiu 2013, 40 (1):  81-83.  Abstract ( 1427 )   PDF (810KB) ( 5364 )   Objective：To investigate high risk human papillomavirus（HR-HPV） prevalence among women in Nanning and to study the high risk factors． Methods：During January 2009 to December 2011，a total of 3 902 women sampled in Nanning by HR-HPV DNA test and cytological tesk.The interview was carried out with unified questionnaires．The data were analyzed in SPSS 13.0． Results：①The HPV infection rate was 23．9％． ②The age distribution of HPV infection was the highest（91.3％） in＜20 age group；then the rate was descended as the age raising，the rate of 25 to 49 age group was stable at 20％，HPV infection rate of different age groups was highly statistically significant（χ2 = 170.404 3； P= 0.000）. In different occupations and different ethnic women HPV infection rate was not statistically significant. ③The positive rate of HPV detection in genotyping assay group was HPV-52，16，58，18，respectively. The percentage of multiple infections was 36.3%，both are high risk of multiple infections or high-risk with low-risk type of multiple infections. Conclusions：The HPV infection rate among different aged women was significant difference,the high risk population which should strengthen screening was the women with more than one sexual partner or more than one pregnancy,the sustained infection women should be checked regularly intend to early detection of cervical lesions and cervical cancer. Related Articles | Metrics

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The Efficiency and Safety of Postoperative Adjuvant Chemoradiotherapy in Cervical Cancer： a Meta-analysis LU Yun;BI Xue-han;YANG Yong-xiu 2013, 40 (1):  84-88.  Abstract ( 1453 )   PDF (1961KB) ( 5270 )   Objective：To evaluate the efficiency and safety of postoperative adjuvant concurrent chemoradiotherapy（CCRT） and radiotherapy（RT） alone in cervical cancer. Methods：By searching VIP， CNKI， CBM， Wanfang database， PubMed， EMBASE， The Cochrane Library，the studies were included if they are accord with inclusion criteria. Data were extracted and evaluated by two reviewers independently and data were analyzed using RevMan 5.1.1. Results：8 studies were included with a total of 892 patients. Meta-analysis results are as follows： CCRT group 3-years disease-free survival rate（RR=1.22， 95%CI：1.04-1.44， P=0.01）， the incidence of radioactive cystitis（RR=1.26， 95%CI：1.01-1.58， P=0.04）， bone marrow suppression（RR=2.30， 95% CI：1.67-3.15， P＜0.000 01） and gastrointestinal reaction（RR=1.55， 95% CI：1.20-2.02， P=0.001） are higher than the RT group， while pelvic recurrence （RR=0.50， 95%CI：0.36-0.69， P＜0.000 1） and distant metastasis（RR=0.66， 95%CI：0.48-0.91， P=0.01） lower than the RT group， the difference have statistical significance. However， there were no statistically differences on the 5-years over-all survival（RR=1.24， 95%CI：0.98-1.56， P=0.07） and radiation proctitis（RR=1.01， 95%CI：0.83-1.23，P=0.91）. Conclusions：Compared with CCRT and alone RT in cervical cancer. The former can significantly improve the 3-years disease-free survival， decrease the pelvic recurrence and distant metastasis， while it can increase radiation cystitis， bone marrow suppression and gastrointestinal reactions. It should be take patients’ condition into account when treatment measure was selected by clinical physicians. Simultaneously， the adverse reactions which associated with CCRT should be treated timely. Related Articles | Metrics

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The Relationship Between HIF-1α and Cervical Cancer: A Meta-analysis of Case-Control Studies DI Xiao-hong;LYU Rui 2013, 40 (1):  89-92.  Abstract ( 1530 )   PDF (2419KB) ( 5150 )   Objective：To explore the expression of HIF-1α in cervical cancer and evaluate their relationship. Methods：The published studies were searched in the CNKI （1979 to 2010）， VIP （1989 to 2010），CBMdisc （1979 to 2010） and Wanfang technological periodical full-text databases（1982 to 2010） and other relevant journals were also searched by hand， to identify all the relevant case-control trials，and the quality of the included studies were assessed. The data were analyzed by RevMan 5.0 software. Results：A total of 13 studies involving 862 patients and 243 controls were recruited. Meta-analysis results showed that the positive rate of HIF-1α expression in cervical cancer was significant higher than normal cervical tissues（OR=54.72，95%CI：28.87-103.70），and no significant differences was tested between cervical squamous cell carcinoma vs. non-squamous cell carcinoma（OR=0.82，95%CI：0.39-1.75），and significant differences was tested between lymphnode metastasis vs. no lymphnode metastasis， poorly differentiatedand vs. well differentiated with OR（95%CI） at 6.24 （2.90-13.44）， 5.00（3.18，7.88） respectively. Conclusions：The expression of HIF-1α is significantly associated with cervical cancer and its biological behavior. Related Articles | Metrics

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Expression and Correlation of GPR30 and EGFR in Endometrial Adenocarcinoma and Its Clinical Significance ZHU Qi-zhou;SHU Kuan-yong 2013, 40 (1):  93-96.  Abstract ( 1370 )   PDF (2539KB) ( 5079 )   Objective：To explore the expression and clinical significance of G protein-coupled receptor 30（GPR30） during carcinogenesis of endometrium. Methods：The expression of GPR30 and EGFR in 20 cases of endometrial atypical hyperplasia （EAH group） and 50 cases of endometrial carcinoma （EAC group） were detected by immunohistochemical EliVision two stages method. Another 20 cases of normal endometrial tissue specimen were as a control group. Results：In group of control， EAH group and EAC group， the positive rates of GPR30 were 10.0%，45.0% and 74.0%，respectively. The differences among the three groups was statistically significant（P＜0.001），EAH group was significantly higher than the control group（P＜0.05）， and significantly lower than the EAC group（P＜0.05）. In EAC patients， the expression of GPR30 was not associated with age，surgery-pathological stage， depth of myometrial invasion， tumor size and lymph node metastasis（P＞0.05，respectively） but the type of histology，the expression of GPR30 with different tumor grade showed a significant statistical difference（P＜0.05）. The expression rates of EGFR in normal endometrium，EAH and EAC tissues were 30.0%， 40.0% and 70.0%， respectively， showing a rising trend. The positive expression rate and expression intensity of EGFR in EAC group was significantly higher than that in EAH group or control group （P＜0.05，P＜0.001， respectively），but the difference of that between EAH group and control group were no statistical significance（P＞0.05）. In the EAC group， EGFR positive expression intensity correlated with FIGO stage， histopathological grade or tumor diameter （P＜0.05，respectively），its expression did not correlate with any other clinicopathological parameters（P＞0.05）. Positively correlation between the expression of GPR30 and that of EGFR was observed in EAC group （r=0.308，P＜0.05） Conclusions：GPR30 and EGFR probably have relationships with the occurrence and development of endometrial carcinoma. GPR30 and EGFR expression in endometrial adenocarcinoma was positively correlated with each other， there could be interaction between the two. GPR30 and EGFR could be more effective novel therapeutic targets of endometrial cancer. Related Articles | Metrics

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Aberrant Methylation and the Expression of the Human Hedgehog Interacting Protein Gene in Endometrial Carcinoma ZHAO Huan;FENG Yu-zhen;PANG Yi-cun 2013, 40 (1):  97-99.  Abstract ( 1414 )   PDF (2573KB) ( 5096 )   Objective：To investigate the aberrant methylation and the expression of Hedgehog Interacting Protein （HHIP） gene in endometrial carcinoma，and to explore the possible relationship between the methylation of the gene and the expression of the gene and their effect on the carcinogenesis and the proliferation of the endometrial carcinoma. Methods：The promoter methylation status of HHIP gene was tested by methylation-specific PCR in 20 normal endometrium tissus and 30 endometrial carcinoma tissus. The expression of HHIP was studied by histochemistry in 20 cases of normal endometrium and 30 cases of endometrial carcinoma.The correlation between the methylation status and endometrial carcinoma ，the correlation between the HHIP silencing and endometrial carcinoma as well as the correlation between the methylation status and the silencing of HHIP were tested by SPSS 13.0. Results：The frequencies of hepermethylation of HHIP in normal endometrium tissues were 0%（0/20），while the frequencies of heper-methylation of HHIP in endometrial carcinoma tissue were 40%（12/30）. The methylation rate in endometrial carcinoma tissue was higher than the methylation rate in normal endometrium tissue. All the normal endometrium tissues showed positive staining pattern of HHIP protein（20/20）. 40%（8/20） of endometrial carcinoma tissues showed positive staining pattern of HHIP protein. In endometrial cancer， the HHIP protein silencing was easier to be found than in the normal endometrium tissue.The hepermethylation of HHIP gene was not related with the expression of HHIP protein（P＞0.05）. Conclusions：HHIP is related to the occurrence and the development of the endometrial carcinoma. The methylation rate in endometrial carcinoma tissue is higher than that in normal endometrium tissue. In endometrial cancer， the HHIP protein silencing is easier to be found than in the normal endometrium tissue. The methylation of the HHIP gene promoter may be related to the silencing of the expression of the protein to some extent，and it may be involved in the occurrence of the endometrial carcinoma. However， methylation may not be the only reason for the silencing of the expression of HHIP， and other mechanisms remain to be revealed. Related Articles | Metrics