Abstract: Polycystic ovary syndrome（PCOS），whose etiology is still not clear，is a common endocrine disorder of reproductive-age female. More and more researches indicate that hyperinsulinemia and insulin resistance play an important role in the occurrence and development of PCOS in recent decades. Usually，we use a variety of animal models for the study of it’s pathogenesis and therapeutic effect. Common polycystic ovary animal model manufacturing methods include androgen， androgen+hCG， estrogen method， letrozole method， insulin + hCG method， progesterone + hCG method， this paper summarizes the insulin resistance performance of common animal models of polycystic ovary syndrome ， and to explore which model is more suitable for the study of insulin resistance in the occurrence and development of the disease.

Key words: Polycystic ovary syndrome, Disease models, animal, Insulin resistance