Abstract: Objective：To investigate high risk human papillomavirus（HR-HPV） prevalence among women in Nanning
and to study the high risk factors． Methods：During January 2009 to December 2011，a total of 3 902 women sampled in Nanning by HR-HPV DNA test and cytological tesk.The interview was carried out with unified questionnaires．The data were analyzed in SPSS 13.0． Results：①The HPV infection rate was 23．9％． ②The age distribution of HPV infection was the highest（91.3％） in＜20 age group；then the rate was descended as the age raising，the rate of 25 to 49 age group was stable at 20％，HPV infection rate of different age groups was highly statistically significant（χ2 = 170.404 3； P= 0.000）. In different occupations and different ethnic women HPV infection rate was not statistically significant. ③The positive rate of HPV detection in genotyping assay group was HPV-52，16，58，18，respectively. The percentage of multiple infections was 36.3%，both are high risk of multiple infections or high-risk with low-risk type of multiple infections. Conclusions：The HPV infection rate among different aged women was significant difference,the high risk population which should strengthen screening was the women with more than one sexual partner or more than one pregnancy,the sustained infection women should be checked regularly intend to early detection of cervical lesions and cervical cancer.

Key words: Nanning, Papillomaviridae, Epidemiology, Logistic models