Abstract: Objective：To discuss the differences between the cervical lesions induced by single hr-HPV and multiple hr-HPV infection，by comparing the liquid-based cytology and biopsy pathological results of all the cases. Methods：Compare the probability of all the LCT and pathologic results. Compare the differences between the cervical lesions，which were induced by single hr-HPV and multiple hr-HPV infections. Results：①In all the infection cases，the most common age was from 20 to 49， and the incident rate went down along with the age increasing.②In all the infection cases，HPV16 was the most frequent type. ③In all the cases of high grade cervical lesions，HPV16 was the most frequent type.④Compare of the single hr-HPV and multiple hr-HPV infections，there were no significant differences between the cervical lesions. ⑤CINⅡ-Ⅲ lesions，which induced by pure hr-HPV infections were higher than mixed HPV infections，in opposition to low grade cervical lesions. Conclusions：①Compare with single hr-HPV infection，the cervical lesions，which induced by the multiple hr-HPV infections，is not obvious. ②Compare with single hr-HPV infections，the mixed HPV infections induced more low grade cervical lesions.

Key words: Human papillomavirus 6, Human papillomavirus 11, Human papillomavirus 16, Human papillomavirus 18, Uterine cervical diseases, Cytodiagnosis