Study on the HPV Infection and Its Correlation with Cervical Columnar Ectopy

doi:10.12280/gjfckx.20210113

Abstract

Abstract:

Objective:To study the human papilloma virus (HPV) infection conditions in patients from gynecology outpatient department and its correlation with cervical columnar ectopy, to provide clinical evidence for prevention and treatment of HPV infection.Methods: Selected 1 130 patients who accepted cervical HPV screening in the gynecology outpatient department of the Second Affiliated Hospital of Tianjin University of TCM from May 2018 to December 2019 as the research subjects, age ranged from 21 to 65 years old, and the main reasons for visiting included reproductive endocrine diseases, abnormal vaginal secretions, previous HPV infection, gynecological tumors, endometriosis and gynecological physical examination, recorded the appearance of cervix simultaneously, detected HPV using fluorescent polymerase chain reaction technology, and analyzed the conditions of HPV infection and its correlation with ages, reasons for medical visits and cervical appearance.Results: The overall HPV infection rate was 40.00% (452/1 130). The top five of the most common types of HPV infection were 16, 58, 52, 51 and 18 in order. The HPV infection rate was the highest in the 60-65 years old group, accounting for 74.07%. The HPV infection rate was the highest in patients with abnormal vaginal discharge (54.57%), followed by patients with previous HPV infection (50.77%). There was no statistical difference (P>0.05) between cervical columnar ectopy group and smoothy cervix group including total HPV infection rate (39.94% vs. 40.08%), high-risk HPV(HR-HPV) infection rate (33.75% vs. 34.09%), low-risk HPV infection rate (4.33% vs. 3.93%), possible HR-HPV infection rate (1.86% vs. 2.07%), single subtype HPV infection rate (28.95% vs. 28.10%) and multiple HPV infection rate (10.99% vs. 11.98%).Conclusions: There is no relationship between HPV infection and cervical columnar ectopy. We should strengthen the HPV screening for patients with advanced age, abnormal vaginal secretions, and previous HPV infection in clinical work, detect persistent HPV infection in time, and make targeted interventions to effectively prevent cervical cancer and precancerous lesion.

Key words: Human papilloma virus DNA tests, Papillomaviridae, Cervical columnar ectopy, Uterine cervical diseases, Superinfection

CHEN Xiu-jie, WANG Qiang, WANG Ya-nan, GUO Jie, ZHAO Lin, ZHANG Wei, SONG Dian-rong. Study on the HPV Infection and Its Correlation with Cervical Columnar Ectopy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 710-713.

Figures/Tables 2

References 13

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HPV亚型	单一感染（n）	双重感染（n）	三重感染（n）	四重感染（n）	五重感染（n）	六重感染（n）	总感染数（n）	感染率（%）
高危型
HPV16	73	22	8	3	3	1	110	9.73
HPV18	22	13	4	2	0	0	41	3.63
HPV31	8	6	5	1	0	0	20	1.77
HPV33	7	2	4	0	1	1	15	1.33
HPV35	2	1	0	1	0	0	4	0.35
HPV39	9	5	4	3	1	0	22	1.95
HPV45	13	6	1	0	1	0	21	1.86
HPV51	24	11	7	4	0	0	46	4.07
HPV52	34	19	7	1	1	0	62	5.49
HPV56	9	4	4	2	2	1	22	1.95
HPV58	33	20	9	3	1	1	67	5.93
HPV59	7	10	4	1	0	1	23	2.04
HPV66	6	4	3	1	3	0	17	1.50
HPV68	13	5	3	1	0	0	22	1.95
疑似高危型
HPV53	14	5	7	3	0	0	29	2.57
HPV73	5	1	0	0	0	1	7	0.62
HPV82	2	2	2	1	0	0	7	0.62
低危型
HPV6	13	3	3	1	0	0	20	1.77
HPV11	5	0	2	2	0	0	9	0.80
HPV42	11	11	4	3	2	0	31	2.74
HPV43	4	6	4	2	3	0	19	1.68
HPV44	1	4	3	1	0	0	9	0.80
HPV81	8	10	2	0	2	0	22	1.95

HPV亚型	单一感染（n）	双重感染（n）	三重感染（n）	四重感染（n）	五重感染（n）	六重感染（n）	总感染数（n）	感染率（%）
高危型
HPV16	73	22	8	3	3	1	110	9.73
HPV18	22	13	4	2	0	0	41	3.63
HPV31	8	6	5	1	0	0	20	1.77
HPV33	7	2	4	0	1	1	15	1.33
HPV35	2	1	0	1	0	0	4	0.35
HPV39	9	5	4	3	1	0	22	1.95
HPV45	13	6	1	0	1	0	21	1.86
HPV51	24	11	7	4	0	0	46	4.07
HPV52	34	19	7	1	1	0	62	5.49
HPV56	9	4	4	2	2	1	22	1.95
HPV58	33	20	9	3	1	1	67	5.93
HPV59	7	10	4	1	0	1	23	2.04
HPV66	6	4	3	1	3	0	17	1.50
HPV68	13	5	3	1	0	0	22	1.95
疑似高危型
HPV53	14	5	7	3	0	0	29	2.57
HPV73	5	1	0	0	0	1	7	0.62
HPV82	2	2	2	1	0	0	7	0.62
低危型
HPV6	13	3	3	1	0	0	20	1.77
HPV11	5	0	2	2	0	0	9	0.80
HPV42	11	11	4	3	2	0	31	2.74
HPV43	4	6	4	2	3	0	19	1.68
HPV44	1	4	3	1	0	0	9	0.80
HPV81	8	10	2	0	2	0	22	1.95

宫颈外观	n	HPV 总阳性	高危型 HPV感染	低危型 HPV感染	疑似高危型 HPV感染	单一型别 HPV感染	多重型别 HPV感染
宫颈光滑	646	258（39.94）	218（33.75）	28（4.33）	12（1.86）	187（28.95）	71（10.99）
宫颈柱状上皮异位	484	194（40.08）	165（34.09）	19（3.93）	10（2.07）	136（28.10）	58（11.98）
χ²		0.002	0.015	0.116	0.063	0.098	0.270
P		0.961	0.904	0.733	0.802	0.755	0.604

宫颈外观	n	HPV 总阳性	高危型 HPV感染	低危型 HPV感染	疑似高危型 HPV感染	单一型别 HPV感染	多重型别 HPV感染
宫颈光滑	646	258（39.94）	218（33.75）	28（4.33）	12（1.86）	187（28.95）	71（10.99）
宫颈柱状上皮异位	484	194（40.08）	165（34.09）	19（3.93）	10（2.07）	136（28.10）	58（11.98）
χ²		0.002	0.015	0.116	0.063	0.098	0.270
P		0.961	0.904	0.733	0.802	0.755	0.604

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