Role of STING Signaling Pathway in HPV-Related Malignant Tumors

doi:10.12280/gjfckx.20220376

Abstract

Abstract:

Stimulator of interferon genes (STING) signaling pathway is a natural immune pathway, which can be activated by bacterial or viral DNA fragments in cytoplasm to promote type I interferon production through a series of downstream signaling pathways. It is a central part of the human anti-tumor immunity. Previous studies have found that STING expression was up-regulated in some human papilloma virus (HPV)-positive tumor tissues, and high expression of STING was associated with a better prognosis of tumor patients. We could observed remarkable regression of tumor when injecting STING agonists into tumor tissues. However, other studies believe that the immune escape of HPV could interfere with STING signaling pathways and other natural immune pathways at the transcriptional level, promote epigenetic silencing and autophagy degradation of STING, thus creating an immunosuppressive microenvironment of tumor and promoting tumor growth. Herein we will systematically elaborate the role of STING signaling pathway in HPV-positive malignant tumors and analyze the potential therapeutic value of STING agonists in HPV-positive tumors.

Key words: Interferons, Papillomaviridae, Neoplasms, Signal transduction, Stimulator of interferon genes

ZHANG Zhan, LIU Zhao-hui. Role of STING Signaling Pathway in HPV-Related Malignant Tumors[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 30-34.

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