Abstract:

Cervical squamous cell carcinoma that spreads superficially to the inner surface of the endometrium has been rarely reported. There is still lack of clinical guidance for this disease entity. In this paper, we report a case of a 60-year-old woman who presented to our hospital with "abnormal postmenopausal vaginal discharge" and was positive for human papillomavirus 16, followed by laparoscopic total hysterectomy and bilateral salpingo-oophorectomy. Postoperative pathological findings showed that the high-grade squamous intraepithelial lesions of the cervix involved the glands and spread widely superficially to the endometrium and involved the plasma surface of the right ovary. All the lesions showed consistent high expression of p16 and Ki-67. We summarize the previous reports and the characteristics of this case in order to provide evidence for early diagnosis and treatment of the disease and improve clinical prognosis.

Key words: Uterine cervical neoplasms, Carcinoma, squamous cell, Endometrium, Ovary, Papillomaviridae, Case reports