Journal of International Obstetrics and Gynecology ›› 2013, Vol. 40 ›› Issue (1): 84-88.

• 论著 • Previous Articles     Next Articles

The Efficiency and Safety of Postoperative Adjuvant Chemoradiotherapy in Cervical Cancer: a Meta-analysis

LU Yun, BI Xue-han,YANG Yong-xiu   

  1. Department of Obstetrics and Gynecology, the First Hospital of Lanzhou University, Lanzhou 730000, China(LU Yun, BI Xue-han,YANG Yong-xiu);The First Clinical College of Lanzhou University, Lanzhou 730000, China(LU Yun)
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-02-15 Online:2013-02-15
  • Contact: YANG Yong-xiu

Abstract: Objective:To evaluate the efficiency and safety of postoperative adjuvant concurrent chemoradiotherapy(CCRT) and radiotherapy(RT) alone in cervical cancer. Methods:By searching VIP, CNKI, CBM, Wanfang database, PubMed, EMBASE, The Cochrane Library,the studies were included if they are accord with inclusion criteria. Data were extracted and evaluated by two reviewers independently and data were analyzed using RevMan 5.1.1. Results:8 studies were included with a total of 892 patients. Meta-analysis results are as follows: CCRT group 3-years disease-free survival rate(RR=1.22, 95%CI:1.04-1.44, P=0.01), the incidence of radioactive cystitis(RR=1.26, 95%CI:1.01-1.58, P=0.04), bone marrow suppression(RR=2.30, 95% CI:1.67-3.15, P<0.000 01) and gastrointestinal reaction(RR=1.55, 95% CI:1.20-2.02, P=0.001) are higher than the RT group, while pelvic recurrence (RR=0.50, 95%CI:0.36-0.69, P<0.000 1) and distant metastasis(RR=0.66, 95%CI:0.48-0.91, P=0.01) lower than the RT group, the difference have statistical significance. However, there were no statistically differences on the 5-years over-all survival(RR=1.24, 95%CI:0.98-1.56, P=0.07) and radiation proctitis(RR=1.01, 95%CI:0.83-1.23,P=0.91). Conclusions:Compared with CCRT and alone RT in cervical cancer. The former can significantly improve the 3-years disease-free survival, decrease the pelvic recurrence and distant metastasis, while it can increase radiation cystitis, bone marrow suppression and gastrointestinal reactions. It should be take patients’ condition into account when treatment measure was selected by clinical physicians. Simultaneously, the adverse reactions which associated with CCRT should be treated timely.

Key words: Uterine cervical neoplasms, Postoperative period, Combined modality therapy, Radiotherapy, Drug therapy, Meta-analysis as topic